Despite the potential benefits of sequential designs. studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs. Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field and to clearly illustrate its potenti... https://www.diegojavierfares.com/mega-super-Custom-Moulded-Cargo-Boot-Liner-Suits-Citroen-Grand-C4-Picasso-9-2006-On-Wagon-EXP-CARCRN00026-best-super/