Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines. Here. we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in combination with immune checkpoint blockade (ICB). Current cancer ICB benefits only a small subset of patients. https://www.bekindtopets.com/mega-grab-Bee-Gold-Teaspoon-on-sale/