Addition of small molecule Retro-1 has been described to enhance antisense and splice switching oligonucleotides. With the aim of assessing the effect of covalently linking Retro-1 to the biologically active oligonucleotide. three different derivatives of Retro-1 were prepared that incorporated a phosphoramidite group. a thiol or a 1. https://www.socialstudiesscholar.com/