Ineffective hematopoiesis is the major characteristic of early myelodysplastic syndromes. Its pathophysiology relies on a diversity of mechanisms supported by genetic events that develop in aging hematopoietic stem cells. Deletion and mutations trigger epigenetic modifications. and co-transcriptional and post-transcriptional deregulations of gene expression. https://www.roneverhart.com/117-Varick-Street-Tribeca-NY-1914/