Abstract Background Hyposalivation is treated using oral cholinergic drugs; however. systemic side effects occasionally lead to discontinuation of treatment. We aimed to investigate the effects of transdermal pilocarpine on the salivary gland skin on saliva secretion and safety in rats. Methods Pilocarpine was administered to rats orally (0. https://parisnaturalfoodes.shop/product-category/aloe-w-vit-e/