Abstract Efficient cytosolic delivery of RNA molecules remains a formidable barrier for RNA therapeutic strategies. Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver RNA molecules intracellularly. as exemplified by the recent implementation of several vaccines against SARS-CoV-2. Using a bottom-up rational design approach. https://macorners.shop/product-category/pet-loss-frame/